Meet The Team
Marcos graduated from the University of Buenos Aires in 2005. For his PhD he moved to Italy, to work in the laboratory of Dr Andres F. Muro. His findings on the mechanisms of mRNA regulation mediated by 3’UTRs resulted in two first and co-corresponding author publications. For his postdoctoral studies, he had a joint appointment between the laboratory of Prof. Donal O’Carroll at the European Molecular Biology Laboratory (EMBL) in Italy and the research group of Dr Anton Enright at the European Bioinformatics Institute (EBI) in the United Kingdom. During this time, Marcos worked on the physiological relevance of RNA modifications in mammals. He developed some of the first animal models for terminal nucleotidyl transferases (TENTs), a family of enzymes that modify RNA post-transcriptionally, and showed the importance of RNA modifications during germline development. During the final years of his postdoc, he moved, with the O’Carroll lab, to the MRC Centre for Regenerative Medicine in Edinburgh.
Yin received a B.S. degree from Shenyang Pharmacy University, China, and a Ph.D. degree from The University of Tokyo, Japan. She moved to the United States in 1993 for her post‐doctoral training at Sanford Burnham Prebys Medical Discovery Institute, La Jolla. She then joined Columbia University Medical Center as a research scientist and a lab manager. In 2004, Yin joined NIEHS as a biologist to study estrogen receptors (ERs)/estrogen related receptors (ERRs) and actions of an endocrine-disrupting chemical (EDC) using both in vitro and in vivo models. Recently, Yin’s research projects investigated ER-mediated transcriptome alteration and DNA methylation reprogramming in the male mouse reproductive tissues following early DES exposure. Yin has published many first-authored and co-authored research articles in the fields of nuclear receptor, cancer research, and environmental research science.
Lokesh received his M.Sc. degree in Biotechnology from Kumaun University Nainital, India, and a Ph.D. degree from CSIR-Central Drug Research Institute, Lucknow, India. His thesis supervisor was Dr. Gopal Gupta, a recognized expert on contraception and male reproduction. During his Ph.D. training, he explored the biochemical and metabolic events occurring in sperm during quiescence(pre-ejaculation) in cauda epididymis and motility activation(post-ejaculation). He presented proof of concept studies to identify the novel targets on sperm that could be made vulnerable to designed chemical interference for contraception. During his Post-doctoral experience at the India Institute of Technology, Roorkee, India, he worked on the role of miRNAs of germ cells regulating the energy metabolism in male infertility associated with obese/type 2 diabetes. He published more than ten peer-reviewed articles in highly regarded journals in the field of reproductive biology and andrology.
Marine received her Ph.D. from Clermont Auvergne University, France, in 2014. As a graduate student in the laboratory of Dr. David H. Volle, she investigated the impact of bile acids (BA) on spermatogenesis. In particular, she characterized how the BA-mediated activation of the Tgr5 receptor in the testis affects male fertility. After receiving her Ph.D., Marine joined the laboratory of Michael A. Cowley at North Carolina State University. During her postdoc, she continued investigating the effect of environmental factors, particularly diet, upon liver physiology and its systemic impact. Her investigations ranged from behavioral studies to the molecular characterization of metabolic dysregulation. Marine’s work has been critical to clarify the molecular links between liver metabolic dysfunctions and reduced male fertility.